You Know What's Über-Annoying?

Is when I talk to a friend of mine and no matter how long I wait he seldom ever responds. I mean we [somehow] got a conversation rolling on Saturday but now...are we really meant to be friends. I wonder about the same thing with my other friend on Facebook...but with him it's like so long as he's logging in and doing something be it join a group, add a friend, etc then I'm pretty okay. But with this other friend....I've known him for what feels like the longest time and just recently we don't talk and fiddle around with the smilies as much as we used to, you know? I've known both of these people for the longest time and neither one of them are talking to me for reasons I don't understand and it's making me feel like I've done something wrong with both of them. I'd like to know what it is but I am afraid to ask them for fear that they might be mad at me...or more so if they're already mad. What have I done? One friend I just talk to and the other I sent a quote that he seemed to take well in my opinion. So...I don't know what the problem is. I wish I knew so I can rectify this mess....if it really is a mess. And if it's not a mess and it's a case of them not wanting to be my friend anymore, then I'll be devastated because I miss them both like crazy...have for quite some time. But I think I know why one of them is not talking to me and I hope it's not because that one of my friends has a girlfriend that he talks to, I'm betting, on a daily basis. I wish he talked to me like he talks to her. :(

Other than that, there's nothing big going on, minus my medication.